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[Early in the space shuttle program, astronauts were required to take Scop-dex either just before launch, or just after MECO, but it didn't seem to make any difference...now astronauts can decide whether to take it or not]

Men and women have both experienced space sickness. Not many women have had the opportunity to go into space, so the statistics aren't reliable, but so far the percentage of women who have gotten sick is lower than that of men. There have been, and will be, all kinds of theories on causes of space sickness and proposals for possible antedotes. I've even heard people mistakenly claim that no astronauts have gotten sick on flights that included women, contending that the men on the crew would have been too embarrassed to allow themselves to get sick!

Space sickness is not like classic "sea sickness". It can take many forms, and its symptoms vary from person to person. Unlike sea sickness it is usually not a debilitating condition: those astronauts who are affected are still able (though sometimes reluctantly) to carry out their duties.
[variety of symptoms] the symptoms usually disappear by the third day on orbit. With that in mind, NASA doesn't schedule spacewalks before the fourth day of a flight--by then all astronauts should be in good physical condition.
In orbit there is no force pulling fluid in the body toward the feet, so it tends to shift "upward" toward the head.